acdc – Automated Contamination Detection and Confidence estimation for single-cell genome data
نویسندگان
چکیده
منابع مشابه
Automated Contamination Detection in Single-Cell Sequencing
Novel methods for the sequencing of single-cell DNA offer tremendous opportunities. However, many techniques are still in their infancy and a major obstacle is given by sample contamination with foreign DNA. In this contribution, we present a pipeline that allows for fast, automated detection of contaminated samples by the use of modern machine learning methods. First, a vectorial representatio...
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Once a failure is observed, the primary concern of the developer is to identify what caused it in order to repair the code that induced the incorrect behavior. Until a permanent repair is afforded, code repair patches are invaluable. The aim of this work is to devise an automated patch generation technique that proceeds as follows: Step1) It identifies a set of failure-causing control dependenc...
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Single cell whole-genome sequencing (scWGS) is providing novel insights into the nature of genetic heterogeneity in normal and diseased cells. However, the whole-genome amplification process required for scWGS introduces biases into the resulting sequencing that can confound downstream analysis. Here, we present a statistical method, with an accompanying package PaSD-qc (Power Spectral Density-...
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در این پایان نامه به بررسی روش های آشکارسازی در سیستم های mc-cdma می پردازیم. با توجه به ماهیت آشکارسازی در این سیستم ها، تکنیک های آشکارسازی را می توان به دو دسته ی اصلی تقسیم نمود: آشکارسازی سیگنال ارسالی یک کاربر مطلوب بدون در نظر گرفتن اطلاعاتی در مورد سایر کاربران تداخل کننده که از آن ها به عنوان آشکارساز های تک کاربره یاد می شود و همچنین آشکارسازی سیگنال ارسالی همه ی کاربران فعال موجود در...
Monodisperse Picoliter Droplets for Low-Bias and Contamination-Free Reactions in Single-Cell Whole Genome Amplification
Whole genome amplification (WGA) is essential for obtaining genome sequences from single bacterial cells because the quantity of template DNA contained in a single cell is very low. Multiple displacement amplification (MDA), using Phi29 DNA polymerase and random primers, is the most widely used method for single-cell WGA. However, single-cell MDA usually results in uneven genome coverage becaus...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2016
ISSN: 1471-2105
DOI: 10.1186/s12859-016-1397-7